Endocrine Abstracts

Context: Metformin is an established therapy for women with PCOS and pre-diabetes or diabetes when lifestyle modification is insufficient. Metformin should also be considered in women with PCOS with BMI≥25 kg/m2 independently of the presence of metabolic disturbances. However, its long-term efficacy in this subset of patients is inadequately studied.Aim: We analyzed collection data of 10 years for the efficacy of metformin on body mass (...

Introduction: An inverse relation was found between testosterone and vasculopathy of the allograft in heart-transplanted men. We evaluated the correlation between serum testosterone levels and graft function early after heart transplantation.Methods: In a cross-sectional study serum total testosterone levels prior to hospital discharge (19±3 postoperative day) was determined in 49 consecutive male patients who underwent heart transplantation between...

Introduction: Growing evidences imply a role of coagulation system in the development of thromboembolic events and progression of atherosclerosis in PCOS. The aim of the study was to identify potential relationship of overall haemostatic potential (OHP) with a syndrome per se, BMI and androgens. OHP has not yet been assessed in PCOS.Methods: In 89 women with PCOS aged 30.9±8.1 years (50 obese, 13 overweight, and 27 normal weight) and 21 hea...

Objective: The weight lowering potential of glucagon-like peptide (GLP) 1 receptor agonists (RAs) is interindividually different and clinically unpredictable. The potential role of genetic variability of GLP1R on body weight response to GLP1 RA has not yet been evaluated. The aim of the study was to assess the effect of common non-synonymous GLP1R single nucleotide polymorphisms (SNPs) rs6923761 and rs10305420 on weight loss in response to long acting GLP1 RA liraglut...

Background: The relationship between obesity, metabolic traits and adrenal incidentaloma (AI) in clinical studies have been discussed mainly in one direction: as the consequences of mild autonomous cortisol secretion in autonomous cortisol secreting AI (ACS) and as possible consequences of minimal hormonal secretion not detectable by current diagnostic methods in non-functioning (NF) AI. However, the observed anabolic and mitogenic effects of insulin on adrenal cortex from pre...

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder of multifactorial etiopathology likely to involve the interactions between genetics and lifestyle. Chronic inflammation and oxidative stress (OS) may participate in the pathophysiology of the syndrome. The question of the extent to which OS and inflammation are causally related to the development of the syndrome and metabolic complications remains unanswered. Furthermore, the role of NLR...

BackgroundMetformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we stop treatment. We compared the effects of metformin withdrawal after long-term (LT) and short term (ST) treatment in PCOS women that had previously well responded to metformin.MethodsWe conduct...

Objective: Diabetes and obesity cause functional hypogonadism (FH) and impair sperm quality. Testosterone replacement therapy (TRT) improves the signs and symptoms of FH but it further deteriorates sperm quality by inhibiting the endogenous gonadal axis. The effect of glucagon-like peptide-1 receptor agonists (GLP-1-RAs) on FH is suggested to be beneficial due to weight loss. However, the effect of GLP-1 RAs on sperm quality in patients with type 2 diabetes mellitus and obesit...

Background: GLP-1 agonism have the potential to affect gastric emptying (GE), yet the reports for subcutaneous semaglutide, currently the most effective GLP-1 RA approved for weight management, remain inconclusive. It has been demonstrated that semaglutide either had no effect on GE or it delayed GE only within the first hour, without late phase retention. Notably, those conclusions were made by an indirect method of estimation of GE through ingestion, absorption and determina...

Objective: During the current pandemic of COVID-19, many therapeutic protocols adopted high dose systemic glucocorticoids (GC) for treatment of moderate to severe respiratory insufficiency. The suppression of the hypothalamic–pituitary–adrenal axis by synthetic GC, even after a short treatment period, cannot be reliably predicted due to pathophysiological changes in cortisol dynamics in critically ill, inter-individual pharmacokinetic differences, and sensitivity var...